Title Abreviation: Eur J Clin Pharmacology
Date of Pub: 1995
Author: PiĶerard-Franchimont C; Goffin V; Visser JN; Jacoby H; PiĶerard GE;
Issue/Part/Supplement: 1-2 Volume Issue: 49
Pagination: 57-60
MESH Headings: Acetic Acids; Acne Vulgaris; Administration, Topical; Adult; Antibiotics, Macrolide; Double-Blind Method; Drug Therapy, Combination; Erythromycin; Human; Male; Sebum; -PG-;
Journal Title Code: EN4
Publication Type: CLINICAL TRIAL
Date of Entry: 960923N
Entry Month: 9611
Country: GERMANY
Index Priority: 2
Language: Eng
Unique Identifier: 96287397
Unique Identifier: 96287397
ISSN: 0031-6970

Abstract:
In a double-blind randomised study, 14 volunteers applied 4% erythromycin plus 1.2% zinc (Zineryt lotion) and 4% erythromycin lotions, each on half of the forehead twice daily for 3 months. The sebum output was evaluated at 3-week intervals using the photometric and the lipid-sensitive film methods. Evaluations of casual level (CL) and sebum excretion rate (SER) were made with a Sebumeter, and total area of lipid spots (TAS) was measured on Sebutapes. Compared to baseline values, the formulation of the erythromycin-zinc complex induced significant reductions in SER after 6 and 9 weeks, and in CL and TAS at 3, 6, 9 and 12 weeks. The mean reduction in TAS was over 20% for four successive 1-h samplings on completion of the study. Significant reductions in CL, SER and TAS were observed for the erythromycin-zinc formulation compared to the control lotion at 6 and 9 weeks, and also at 3 weeks for SER and TAS, and at 12 weeks for CL and TAS. This study indicates that sebum output is significantly reduced by the erythromycin-zinc complex. This reduction is theoretically beneficial for the acneic patient.
Abstract By: Author
Address: Department of Dermatopathology, University of Liege, Belgium.







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