Zinc arginine, a 5 alpha-reductase inhibitor, reduces rat ventral prostate
weight and DNA without affecting testicular function.
Fahim MS; Wang M; Sutcu MF; Fahim Z
Center of Reproductive Science and Technology, University of Missouri,
Andrologia 1993 Nov-Dec; 25 (6): 369-75
LANGUAGE OF ORIGIN
Zinc has been implicated in steroid endocrinology of the prostate gland;
and 5 alpha-dihydrotestosterone (DHT) is believed to express androgenic
responses in the prostate. To note the effect of neutralized zinc (zinc
gluconate + arginine) on the prostate, 50 sexually mature rats, weighing
325 +/- 20 g, were divided into five groups as follows: (1) control, (2)
sham, (3) castrated, and injected intraprostatically with (4) 10 mg neutralized
zinc, and (5) 20 mg neutralized zinc. Results indicated significant reduction
(P < 0.05) of prostate weight, 5 alpha-reductase activity, and total
protein and DNA concentrations in treated prostate tissue; no significant
change in weight and histological structure of testes, epididymides, and
seminal vesicles; and no significant effect on progeny and blood testosterone
level of treated animals. These results suggest that direct application
of neutralized zinc to the prostate offers a new modality for treatment
of prostatitis without affecting spermatogenesis. (AUTHOR)
MJTR: DNA ME. Prostate AH. Testis PH. Testosterone 5-alpha-Reductase
AI. Zinc PD.
MNTR: Animal. Epididymis DE. Female. Male. Organ Weight DE. Pregnancy.
Prostate DE. Prostate ME. Proteins ME. Rats. Rats, Sprague-Dawley. Seminal
Vesicles DE. Testis DE. Testosterone BL. JOURNAL ARTICLE
RNUM: EC 188.8.131.52 (Testosterone 5-alpha-Reductase); 0 (Proteins); 57-85-2
(Testosterone); 7440-66-6 (Zinc); 9007-49-2 (DNA)
IDEN: ISSN: 0303-4569. JOURNAL-CODE: 4QP. ENTRY-DATE: 940210. JOURNAL-SUBSET:
M. IM-DATE: 9404.
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