Charing Cross and Westminster Medical School, Department of Comparative
Biology, London, UK.
Food Chem Toxicol 1991 Jan; 29 (1): 57-64
LANGUAGE OF ORIGIN
The dermal irritancy of six zinc compounds was examined in three animal
models. In open patch tests involving five daily applications, zinc chloride
(1% aqueous solution) was severely irritant in rabbit, guinea-pig and mouse
tests, inducing epidermal hyperplasia and ulceration; aqueous zinc acetate
(20%) was slightly less irritant. Zinc oxide (20% suspension dilute Tween
80), zinc sulphate (1% aqueous solution) and zinc pyrithione (20% suspension)
were not overtly irritant, but induced a marginal epidermal hyperplasia
and increased hair growth. Zinc undecylenate (20% suspension) was not irritant.
Epidermal irritancy in these studies is related to the interaction of zinc
ion with epidermal keratin. The compounds studied were not consistently
bacteriostatic in the three species tested. (AUTHOR)
MJTR: Guinea Pigs. Mice. Rabbits. Skin DE. Zinc TO.
MNTR: Administration, Topical. Animal. Bacillus DE. Bacillus GD. Cell
Division DE. Chlorides AD. Chlorides TO. Epidermis CY. Epidermis ME. Hair
GD. Male. Mitotic Index. Patch Tests. Skin MI. Species Specificity. Staphylococcus
epidermidis DE. Staphylococcus epidermidis GD. Streptococcus DE. Streptococcus
GD. Zinc AD. Zinc PK. Zinc Oxide AD. Zinc Oxide TO. JOURNAL ARTICLE
RNUM: 0 (Chlorides); 1314-13-2 (Zinc Oxide); 7440-66-6 (Zinc); 7646-85-7
IDEN: ISSN: 0278-6915. JOURNAL-CODE: F3U. ENTRY-DATE: 910409. JOURNAL-SUBSET:
M X. IM-DATE: 9106.